Nature Communications (Aug 2016)

DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy

  • Carolina M. Greco,
  • Paolo Kunderfranco,
  • Marcello Rubino,
  • Veronica Larcher,
  • Pierluigi Carullo,
  • Achille Anselmo,
  • Kerstin Kurz,
  • Thomas Carell,
  • Andrea Angius,
  • Michael V. G. Latronico,
  • Roberto Papait,
  • Gianluigi Condorelli

DOI
https://doi.org/10.1038/ncomms12418
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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5-hydroxymethylation of cysteine (5-hmC) plays a role in epigenetic regulation. Here the authors analyse the hydroxymethylome in embryonic, neonatal, adult and hypertrophic mouse cardiomyocytes and show that the dynamic modulation of hydroxymethylated DNA is important for cardiomyocyte gene expression programming in heart development and failure.