Nature Communications (Feb 2023)
TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity
- Sujin Kang,
- Jaekyung Kim,
- Areum Park,
- Minsoo Koh,
- Wonji Shin,
- Gayoung Park,
- Taeyun A. Lee,
- Hyung Jin Kim,
- Heonjong Han,
- Yongbo Kim,
- Myung Kyung Choi,
- Jae Hyung Park,
- Eunhye Lee,
- Hyun-Soo Cho,
- Hyun Woo Park,
- Jae Hee Cheon,
- Sungwook Lee,
- Boyoun Park
Affiliations
- Sujin Kang
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Jaekyung Kim
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Areum Park
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Minsoo Koh
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Wonji Shin
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Gayoung Park
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Taeyun A. Lee
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Hyung Jin Kim
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Heonjong Han
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Yongbo Kim
- Division of Tumor Immunology, Research Institute, National Cancer Center
- Myung Kyung Choi
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Jae Hyung Park
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Eunhye Lee
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Hyun-Soo Cho
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- Hyun Woo Park
- Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University
- Jae Hee Cheon
- Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine
- Sungwook Lee
- Division of Tumor Immunology, Research Institute, National Cancer Center
- Boyoun Park
- Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
- DOI
- https://doi.org/10.1038/s41467-023-36424-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 14
Abstract
The cortical actin cytoskeleton plays a role in maintaining intestinal epithelial integrity. Here the authors report that TRIM40, an E3 ligase, disrupts cortical actin formation and leads to loss of epithelial barrier integrity, and that genetic loss of TRIM40 is protective against experimental colitis in male mice.
