SUPPOSITORIES: ASPECTS OF DOSAGE FORM MODERNIZATION

Abstract

In this material were reviewed biopharmaceutical aspects of suppositories – described the relation between rectal route of administration, bioaccessibility and principles of dosage forms formulation. Also, in the article were shown the physical and chemical characteristics of API, matrix and excipients (surface-active agents, prolongation agents, cyclodextrines, etc.). Was presented information about mucoadhesive suppositories, suppositories with different types of release methods (immediate intensive or prolonged) and poloxamer-based thermo-reversible liquid suppositories (characteristics, pharmaceutical, technological and biopharmaceutical parameters of quality).

Keywords

• suppositories
• mucoadhesive
• thermo-reversible liquid suppositories
• poloxamer