Communications Biology (Dec 2022)
KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells
- Xinhua Zhang,
- Bin Zheng,
- Lingdan Zhao,
- Jiayi Shen,
- Zhan Yang,
- Yu Zhang,
- Ruirui Fan,
- Manli Zhang,
- Dong Ma,
- Lemin Zheng,
- Mingming Zhao,
- Huirong Liu,
- Jinkun Wen
Affiliations
- Xinhua Zhang
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- Bin Zheng
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- Lingdan Zhao
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- Jiayi Shen
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- Zhan Yang
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- Yu Zhang
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- Ruirui Fan
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- Manli Zhang
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- Dong Ma
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- Lemin Zheng
- The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Health Science Center, Peking University
- Mingming Zhao
- The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, and Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education, Health Science Center, Peking University
- Huirong Liu
- Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University
- Jinkun Wen
- Department of Biochemistry and Molecular Biology, the Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University
- DOI
- https://doi.org/10.1038/s42003-022-04302-y
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 17
Abstract
KLF4-induced phenotypic switching of vascular smooth muscle cells occurs in atherosclerosis. Now, KLF4 is shown to induce a glycolytic shift involving upregulation of PFKFB3 expression through circular RNA CTDP1 and eukaryotic elongation factor eEF1A2.
