Nature Communications (Feb 2019)
Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies
- Cheng Zhu,
- Elena Dukhovlinova,
- Olivia Council,
- Lihua Ping,
- Edgar M. Faison,
- Shamit S. Prabhu,
- E. Lake Potter,
- Stephen L. Upton,
- Guowei Yin,
- James M. Fay,
- Laura P. Kincer,
- Ean Spielvogel,
- Sharon L. Campbell,
- S. Rahima Benhabbour,
- Hengming Ke,
- Ronald Swanstrom,
- Nikolay V. Dokholyan
Affiliations
- Cheng Zhu
- Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
- Elena Dukhovlinova
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Olivia Council
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Lihua Ping
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Edgar M. Faison
- Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
- Shamit S. Prabhu
- Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
- E. Lake Potter
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Stephen L. Upton
- Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
- Guowei Yin
- Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
- James M. Fay
- Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
- Laura P. Kincer
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Ean Spielvogel
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Sharon L. Campbell
- Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
- S. Rahima Benhabbour
- Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
- Hengming Ke
- Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
- Ronald Swanstrom
- Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
- Nikolay V. Dokholyan
- Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
- DOI
- https://doi.org/10.1038/s41467-019-08876-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Areas of HIV envelope (Env) that aren’t covered by glycans are potential targets for antibodies. Here, the authors computationally design small protein mimics of four such epitopes and show that they can induce Env binding antibodies in rabbits.
