Enantioselective Synthesis of a New Non-Natural Gabosine

Maximiliano Colobbio; Enrique Pandolfi; Valeria Schapiro

doi:10.3390/molecules26051423

Molecules (Mar 2021)

Enantioselective Synthesis of a New Non-Natural Gabosine

Maximiliano Colobbio,
Enrique Pandolfi,
Valeria Schapiro

Affiliations

Maximiliano Colobbio: Laboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo CP 11800, Uruguay
Enrique Pandolfi: Laboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo CP 11800, Uruguay
Valeria Schapiro: Laboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo CP 11800, Uruguay

DOI: https://doi.org/10.3390/molecules26051423
Journal volume & issue: Vol. 26, no. 5
p. 1423

Abstract

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The preparation of a new non-natural gabosine is reported, in which the chirality is transferred from the toluene’s biotransformed metabolite (1R,2S)-3-methylcyclohexa-3.5-diene-1,2-diol. Further chemical transformations to introduce additional functionality and chirality to the molecule were also accomplished.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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