Nature Communications (Oct 2017)

Genome-wide prediction of DNase I hypersensitivity using gene expression

  • Weiqiang Zhou,
  • Ben Sherwood,
  • Zhicheng Ji,
  • Yingchao Xue,
  • Fang Du,
  • Jiawei Bai,
  • Mingyao Ying,
  • Hongkai Ji

DOI
https://doi.org/10.1038/s41467-017-01188-x
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 17

Abstract

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A map of the activities of all genomic regulatory elements across cell types and conditions would be a tremendous resource. The computational method introduced here predicts genome-wide accessible sites from gene expression data and allows the authors to build a database of regulatory element activities using publicly available transcriptome data.