Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease

Lais M. Oliveira; Marta Ruiz-Lopez; Alexandre Boutet; Gavin J.B. Elias; Suneil K. Kalia; Mojgan Hodaie; Andres M. Lozano; Renato P. Munhoz; Alfonso Fasano

Brain Stimulation (May 2021)

Self-adjustment of deep brain stimulation delays optimization in Parkinson’s disease

Lais M. Oliveira,
Marta Ruiz-Lopez,
Alexandre Boutet,
Gavin J.B. Elias,
Suneil K. Kalia,
Mojgan Hodaie,
Andres M. Lozano,
Renato P. Munhoz,
Alfonso Fasano

Affiliations

Lais M. Oliveira: Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada
Marta Ruiz-Lopez: Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Neurology Department, Cruces University Hospital, Barakaldo, Bizkaia, Spain
Alexandre Boutet: Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Joint Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
Gavin J.B. Elias: Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
Suneil K. Kalia: Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada
Mojgan Hodaie: Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada
Andres M. Lozano: Division of Neurosurgery, University Health Network, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada
Renato P. Munhoz: Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada
Alfonso Fasano: Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Brain Institute, Toronto, Ontario, Canada; CenteR for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, ON, Canada; Corresponding author. Edmond J. Safra Program in Parkinson’s Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Toronto, Ontario, Canada.

Journal volume & issue: Vol. 14, no. 3
pp. 676 – 681

Abstract

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Background: Parkinson’s Disease patients undergo time-consuming programming to refine stimulation parameters after deep brain stimulation surgery. Objective: To assess whether the use of the advanced functions of a patient’s programmer would facilitate programming of deep brain stimulation. Methods: Thirty patients were randomly allocated to the use of advanced versus simple mode of the patient programmer in this single-centre, prospective, randomized, controlled study. Primary outcome was the number of days required to optimize the stimulation settings. Results: The number of days required to optimize stimulation was significantly lower in the simple mode (88.5 ± 33.1 vs. 142.1 ± 67.4, p = 0.01). In addition, the advanced mode group had a higher number of side effects (5.4 ± 3.1 vs. 2.6 ± 1.9, p = 0.0055). Conclusions: The use of the advanced functions of patient programmer delays programming optimization and it is associated with a higher number of side effects. These findings highlight the need for other methods for faster and safer stimulation programming.

Published in Brain Stimulation

ISSN: 1935-861X (Print); 1876-4754 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-stimulation

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