Comparative Study between Topical Latanoprost versus Topical 5- Fluorouracil after Dermabrasion for Treatment of Non-Segmental Stable Vitiligo

Abstract

Background: Latanoprost [LT], a prostaglandin F2-alpha [PGF2α] analogue used in the treatment of glaucoma. It induces skin pigmentation in guinea pigs. The rationale of trying 5-fluorouracil [5‐FU] in vitiligo treatment may come from the first report of hyperpigmentation induced by 5‐FU as a side effect in the skin tumors and psoriasis treatment The Aim of the work: Comparison between the efficacy of topical latanoprost versus topical 5-fluorouracil after skin dermabrasion in induction of skin repigmentation in stable non-segmental vitiligo. Patients and Methods: This study included thirty Egyptian patients, 18-60 years old, with stable non-segmental vitiligo. They were divided into: group [A] patients subjected to 5 fluorouracil after dermabrasion and group [B] patients subjected to latanoprost after dermabrasion then followed up every two weeks for three months. Result: There was no statistically significant difference between both groups regarding total response to treatment and degree of repigmentation. However, there was higher response to treatment in group A than group B. In both groups patients were satisfied with the degree of improvement. As regard complication there were minimal complications only one case of koebnerization and two cases of post inflammatory hyperpigmentation Conclusion: 5- fluorouracil 5% was associated with better improvement than latanoprost. However, the difference did not reach statistical significance. Patients reported high satisfaction with the two treatment modalities.

Keywords

• latanoprost
• five-fluorouracil
• vitiligo
• dermabrasion