Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases

Gonzalo Fernandez Lahore; Michael Förster; Martina Johannesson; Pierre Sabatier; Erik Lönnblom; Mike Aoun; Yibo He; Kutty Selva Nandakumar; Roman A. Zubarev; Rikard Holmdahl

doi:10.1038/s41467-021-25828-5

Nature Communications (Sep 2021)

Polymorphic estrogen receptor binding site causes Cd2-dependent sex bias in the susceptibility to autoimmune diseases

Gonzalo Fernandez Lahore,
Michael Förster,
Martina Johannesson,
Pierre Sabatier,
Erik Lönnblom,
Mike Aoun,
Yibo He,
Kutty Selva Nandakumar,
Roman A. Zubarev,
Rikard Holmdahl

Affiliations

Gonzalo Fernandez Lahore: Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute
Michael Förster: Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute
Martina Johannesson: Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute
Pierre Sabatier: Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute
Erik Lönnblom: Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute
Mike Aoun: Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute
Yibo He: Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute
Kutty Selva Nandakumar: Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute
Roman A. Zubarev: Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute
Rikard Holmdahl: Division Medical Inflammation Research, Dept. Medical Biochemistry and Biophysics, Karolinska Institute

DOI: https://doi.org/10.1038/s41467-021-25828-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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The Cia21 locus on chromosome 3 has been associated with rheumatoid arthritis severity in females. Here the authors show this locus houses a non-coding polymorphic estrogen receptor binding site and how it regulates neighbouring gene expression of CD2, implicating CD2 signalling in the sexual dimorphism of a variety of T cell-dependent autoimmune diseases.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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