The Expression Of Heat Shock Protein (Hsp) 25 At Compression And Tension Area DuringAlveolar Bone Remodeling

Abstract

The activation of orthodontic appliance will generate mechanical force. This force is used to depress tooth and the tissues surrounding it then stimulates alveolar bone remodeling. Alveolar bone remodeling is divided into compression and tension area. This stress becomes a signal to activate heat shock response yielding heat shock protein (HSP) synthesis, especiallyhsp25isessential foralveolarboneremodelingprocessitself. The aim of this study was to compare hsp25 expression in compression and tension areas. This study using guinea pigs mandibular first insicivus that given a mechanical force to see hsp25 expression in both areas. The HSP25 expressionwas measured by counting this protein after being conducted by immunohystochemistry method. It is analysed statistically with one way Anova with level of significant p = 0,05.

Keywords

• heat shock protein (hsp)25
• compression area
• tension area
• alveolar bone remodeling