Investigation of the effects of ketogenic and western diet on tissues lipid peroxidation and antioxidant enzymes in rats with pressure ulcer

Abstract

It was aimed to investigate the effects of different diets on lipid peroxidation and some antioxidant enzymes in the liver, kidney, heart, and serum in rats with pressure ulcers. Thirty adult Spraque Dawley male rats were used. Rats were divided into three groups as standard diet group, ketogenic diet group, and western diet group. The dorsal skins of rats of all groups were squeezed between two neodymium magnetic cylinders while under anesthesia for creating ulcers. The rats were fed with tap water and a specially prepared adlibutum diet according to the determining diets. Malondialdehyde, Glutathione, and Catalase levels were measured by spectrophotometric methods in the liver, kidney, heart, and serum samples taken at the end of the experiment. Malondialdehyde levels in the serum, liver, and kidney decreased in the ketogenic diet group compared to the standard diet group and the western diet group; glutathione levels in the kidney were higher in the western diet group compared to the standard diet and the ketogenic diet groups, and in the heart, it significantly decreased in the standard diet group compared to the ketogenic diet and the western diet groups (p [Med-Science 2021; 10(3.000): 987-91]

Keywords

• ketogenic diet; nutrition; oxidative stress; pressure ulcer; western diet