Ribozyme-mediated RNA synthesis and replication in a model Hadean microenvironment

Annalena Salditt; Leonie Karr; Elia Salibi; Kristian Le Vay; Dieter Braun; Hannes Mutschler

doi:10.1038/s41467-023-37206-4

Nature Communications (Mar 2023)

Ribozyme-mediated RNA synthesis and replication in a model Hadean microenvironment

Annalena Salditt,
Leonie Karr,
Elia Salibi,
Kristian Le Vay,
Dieter Braun,
Hannes Mutschler

Affiliations

Annalena Salditt: Systems Biophysics and Center for NanoScience (CeNS), Ludwig Maximilian University Munich
Leonie Karr: Systems Biophysics and Center for NanoScience (CeNS), Ludwig Maximilian University Munich
Elia Salibi: Department of Chemistry and Chemical Biology, TU Dortmund University
Kristian Le Vay: Department of Chemistry and Chemical Biology, TU Dortmund University
Dieter Braun: Systems Biophysics and Center for NanoScience (CeNS), Ludwig Maximilian University Munich
Hannes Mutschler: Department of Chemistry and Chemical Biology, TU Dortmund University

DOI: https://doi.org/10.1038/s41467-023-37206-4
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 8

Abstract

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Non-equilibrium conditions at heated water-air interfaces can model Hadean microenvironments. Here, the authors show that such conditions enable one-pot synthesis, strand release and folding of functional RNAs similar to modern biological systems.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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