抗氧化剂耦合非生物胁迫调控微藻油脂和类胡萝卜素合成的研究进展Progress on combination of antioxidant and abiotic stress in the regulation of lipid and carotenoid production in microalgae

Abstract

微藻代谢物产率低的问题制约了微藻的产业化发展，近年来利用抗氧化剂耦合非生物胁迫成为有效解决微藻代谢物产率低的方法之一。为了对微藻在非生物胁迫条件下高效合成油脂和类胡萝卜素提供新的思路，综述了抗氧化剂耦合非生物胁迫调控微藻合成油脂和类胡萝卜素的研究进展，并进一步分析了抗氧化剂调控次级代谢产物合成和微藻细胞抗性的作用机制。抗氧化剂可通过调控微藻细胞内氧化还原平衡、信号转导和相关基因的转录水平，维持微藻生长，促进代谢产物的积累，并缓解氧化损伤。 The low yield of microalgae metabolites restricts the industrialization development of microalgae.Recently, coupling of antioxidant and abiotic stress is an efficient method to cope with the low yield of metabolites by microalgae. In order to provide new ideas for the efficient synthesis of lipid and carotenoid by microalgae under abiotic stress conditions, the research progress on the effects of combined antioxidant and abiotic stresses in regulating lipid and carotenoid synthesis by microalgae were reviewed, and the mechanism of action of antioxidants in regulating the synthesis of secondary metabolites and resistance of algal cells was further analyzed. It can be concluded that antioxidants could maintain the growth of microalgae, promote the accumulation of metabolites, and alleviate oxidative damage by regulating intracellular redox balance, signal transduction and the transcription level of related genes.

Keywords

• 微藻；生物量；油脂；类胡萝卜素；抗氧化剂；非生物胁迫
• microalgae; biomass; lipid; carotenoid; antioxidant; abiotic stress