Nature Communications (Apr 2019)
In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers
- Sumiyo Watanabe,
- Kotaro Hayashi,
- Kazuko Toh,
- Hyun Jin Kim,
- Xueying Liu,
- Hiroyuki Chaya,
- Shigeto Fukushima,
- Keisuke Katsushima,
- Yutaka Kondo,
- Satoshi Uchida,
- Satomi Ogura,
- Takahiro Nomoto,
- Hiroyasu Takemoto,
- Horacio Cabral,
- Hiroaki Kinoh,
- Hiroyoshi Y. Tanaka,
- Mitsunobu R. Kano,
- Yu Matsumoto,
- Hiroshi Fukuhara,
- Shunya Uchida,
- Masaomi Nangaku,
- Kensuke Osada,
- Nobuhiro Nishiyama,
- Kanjiro Miyata,
- Kazunori Kataoka
Affiliations
- Sumiyo Watanabe
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Kotaro Hayashi
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- Kazuko Toh
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- Hyun Jin Kim
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Xueying Liu
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- Hiroyuki Chaya
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Shigeto Fukushima
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- Keisuke Katsushima
- Division of Cancer Biology, Nagoya University Graduate School of Medicine
- Yutaka Kondo
- Division of Cancer Biology, Nagoya University Graduate School of Medicine
- Satoshi Uchida
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- Satomi Ogura
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- Takahiro Nomoto
- Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology
- Hiroyasu Takemoto
- Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology
- Horacio Cabral
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- Hiroaki Kinoh
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- Hiroyoshi Y. Tanaka
- Department of Pharmaceutical Biomedicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
- Mitsunobu R. Kano
- Department of Pharmaceutical Biomedicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
- Yu Matsumoto
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Hiroshi Fukuhara
- Department of Urology, Kyorin University Faculty of Medicine
- Shunya Uchida
- Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine
- Masaomi Nangaku
- Division of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo
- Kensuke Osada
- Department of Bioengineering, Graduate School of Engineering, The University of Tokyo
- Nobuhiro Nishiyama
- Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology
- Kanjiro Miyata
- Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
- Kazunori Kataoka
- Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion
- DOI
- https://doi.org/10.1038/s41467-019-09856-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Nanoparticle delivery of siRNA has problems with penetration and off target accumulation. Here, the authors report on the development of Y-shaped block catiomers which dynamically wrap around siRNA; demonstrate increased circulation times and delivery into hard to reach brain and pancreas tumour models.
