Antiproliferative Activity of Natural Flavonoid Fustin Isolated from the Heartwood of Cotinus Coggygria Scop. Against Breast and Colon Cancer Cell Lines

Gospodinova Z.; Antov G.; Novakovic M.; Tesevic V.; Krasteva N.; Pavlov D.; Valcheva-Kuzmanova S.

doi:10.2478/amb-2023-0004

Acta Medica Bulgarica (Apr 2023)

Antiproliferative Activity of Natural Flavonoid Fustin Isolated from the Heartwood of Cotinus Coggygria Scop. Against Breast and Colon Cancer Cell Lines

Gospodinova Z.,
Antov G.,
Novakovic M.,
Tesevic V.,
Krasteva N.,
Pavlov D.,
Valcheva-Kuzmanova S.

Affiliations

Gospodinova Z.: 1Laboratory of Genome Dynamics and Stability, Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences – Sofia, Sofia, Bulgaria
Antov G.: 1Laboratory of Genome Dynamics and Stability, Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences – Sofia, Sofia, Bulgaria
Novakovic M.: 2University of Belgrade-Institute of Chemistry, Technology and Metallurgy, National Institute of the Republic of Serbia – Belgrade, Belgrade, Serbia
Tesevic V.: 3University of Belgrade-Faculty of Chemistry – Belgrade, Belgrade, Serbia
Krasteva N.: 4Department of Electroinduced and Adhesive Properties, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences – Sofia, Sofia, Bulgaria
Pavlov D.: 5Department of Biochemistry, Molecular Medicine and Nutrigenomics with Laboratory of Nutrigenomics, Functional Foods and Nutraceuticals, Faculty of Pharmacy, Medical University “Prof. Dr. Paraskev Stoyanov” – Varna, Varna, Bulgaria
Valcheva-Kuzmanova S.: 6Department of Pharmacology and Clinical Pharmacology and Therapeutics, Faculty of Medicine, Medical University “Prof. Dr. Paraskev Stoyanov” – Varna, Varna, Bulgaria

DOI: https://doi.org/10.2478/amb-2023-0004
Journal volume & issue: Vol. 50, no. 1
pp. 27 – 33

Abstract

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Cotinus coggygria Scop. is a valuable medicinal plant species with pronounced pharmacological potential due to its numerous biological activities. The herb is characterized by a high content of polyphenols among which is fustin. The anticancer activities of fustin, however, are extremely weakly studied. The aim of the present study was to investigate the in vitro antiproliferative potential of fustin isolated from the heartwood of C. coggygria against cell lines originating from two of the most common cancer types – breast (MDA-MB-231 and MCF7), and colon cancer (Colon 26).

Published in Acta Medica Bulgarica

ISSN: 0324-1750 (Print); 2719-5384 (Online)
Publisher: Sciendo
Country of publisher: Poland
LCC subjects: Medicine
Website: https://sciendo.com/journal/AMB

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