Nature Communications (Oct 2020)

Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p

  • Mingyi Qu,
  • Xiaojing Zou,
  • Fang Fang,
  • Shouye Wang,
  • Lei Xu,
  • Quan Zeng,
  • Zeng Fan,
  • Lin Chen,
  • Wen Yue,
  • Xiaoyan Xie,
  • Xuetao Pei

DOI
https://doi.org/10.1038/s41467-020-18802-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Platelets derive from megakaryocytes, which differentiate from hematopoietic stem/progenitor cells (HSPCs). Here, Qu et al show that platelet-derived microparticles carrying miR-1915-3p target HSPCs and promote megakaryopoiesis by suppressing RHOB expression levels.