Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

Elizabeth Haythorne; Maria Rohm; Martijn van de Bunt; Melissa F. Brereton; Andrei I. Tarasov; Thomas S. Blacker; Gregor Sachse; Mariana Silva dos Santos; Raul Terron Exposito; Simon Davis; Otto Baba; Roman Fischer; Michael R. Duchen; Patrik Rorsman; James I. MacRae; Frances M. Ashcroft

doi:10.1038/s41467-019-10189-x

Nature Communications (Jun 2019)

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

Elizabeth Haythorne,
Maria Rohm,
Martijn van de Bunt,
Melissa F. Brereton,
Andrei I. Tarasov,
Thomas S. Blacker,
Gregor Sachse,
Mariana Silva dos Santos,
Raul Terron Exposito,
Simon Davis,
Otto Baba,
Roman Fischer,
Michael R. Duchen,
Patrik Rorsman,
James I. MacRae,
Frances M. Ashcroft

Affiliations

Elizabeth Haythorne: Department of Physiology, Anatomy and Genetics and OXION, University of Oxford
Maria Rohm: Department of Physiology, Anatomy and Genetics and OXION, University of Oxford
Martijn van de Bunt: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
Melissa F. Brereton: Department of Physiology, Anatomy and Genetics and OXION, University of Oxford
Andrei I. Tarasov: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
Thomas S. Blacker: Department of Cell and Developmental Biology, University College London
Gregor Sachse: Department of Physiology, Anatomy and Genetics and OXION, University of Oxford
Mariana Silva dos Santos: The Francis Crick Institute
Raul Terron Exposito: Department of Physiology, Anatomy and Genetics and OXION, University of Oxford
Simon Davis: Discovery Proteomics Facility, Target Discovery Institute, University of Oxford
Otto Baba: Tokushima University Graduate School
Roman Fischer: Discovery Proteomics Facility, Target Discovery Institute, University of Oxford
Michael R. Duchen: Department of Cell and Developmental Biology, University College London
Patrik Rorsman: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
James I. MacRae: The Francis Crick Institute
Frances M. Ashcroft: Department of Physiology, Anatomy and Genetics and OXION, University of Oxford

DOI: https://doi.org/10.1038/s41467-019-10189-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

Read online

Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a multi-omics approach, find that mitochondrial metabolism is perturbed.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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