Study on the interaction between pefloxacin mesylate and bovine serum albumin(甲磺酸培氟沙星与牛血清白蛋白的相互作用研究)

GUOMing(郭明); YIPing-gui(易平贵); ZHAOWen-na(赵文娜); SHANGZhi-cai(商志才); YUQin-sen(俞庆森)

doi:zjup/1008-9497.2003.30.4.434-438

Zhejiang Daxue xuebao. Lixue ban (Jul 2003)

Study on the interaction between pefloxacin mesylate and bovine serum albumin(甲磺酸培氟沙星与牛血清白蛋白的相互作用研究)

GUOMing(郭明),
YIPing-gui(易平贵),
ZHAOWen-na(赵文娜),
SHANGZhi-cai(商志才),
YUQin-sen(俞庆森)

Affiliations

GUOMing(郭明): Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江杭州 310027)
YIPing-gui(易平贵): Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江杭州 310027)
ZHAOWen-na(赵文娜): Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江杭州 310027)
SHANGZhi-cai(商志才): Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江杭州 310027)
YUQin-sen(俞庆森): Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江杭州 310027)

DOI
Journal volume & issue: Vol. 30, no. 4
pp. 434 – 438

Abstract

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应用荧光光谱法研究了喹诺酮抗菌素甲磺酸培氟沙星与牛血清白蛋白分子间的结合反应,测定了结合常数K和结合位点数n,讨论了荧光猝灭机理,并依据Forster非辐射能量转移机制确定了授体-受体间的结合距离和能量转移率.采用同步荧光技术考察了甲磺酸培氟沙星对牛血清白蛋白构象的影响.此外,还探讨了在金属离子Zn2+存在下甲磺酸培氟沙星与牛血清白蛋白的结合作用.

Published in Zhejiang Daxue xuebao. Lixue ban

ISSN: 1008-9497 (Print)
Publisher: Zhejiang University Press
Country of publisher: China
LCC subjects: Science: Mathematics: Instruments and machines: Electronic computers. Computer science; Science: Physics
Website: https://www.zjujournals.com/sci/EN/1008-9497/home.shtml

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