Nature Communications (Jun 2021)
ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
- Kenji Miki,
- Kohei Deguchi,
- Misato Nakanishi-Koakutsu,
- Antonio Lucena-Cacace,
- Shigeru Kondo,
- Yuya Fujiwara,
- Takeshi Hatani,
- Masako Sasaki,
- Yuki Naka,
- Chikako Okubo,
- Megumi Narita,
- Ikue Takei,
- Stephanie C. Napier,
- Tsukasa Sugo,
- Sachiko Imaichi,
- Taku Monjo,
- Tatsuya Ando,
- Norihisa Tamura,
- Kenichi Imahashi,
- Tomoyuki Nishimoto,
- Yoshinori Yoshida
Affiliations
- Kenji Miki
- Center for iPS Cell Research and Application, Kyoto University
- Kohei Deguchi
- Takeda-CiRA Joint program (T-CiRA)
- Misato Nakanishi-Koakutsu
- Center for iPS Cell Research and Application, Kyoto University
- Antonio Lucena-Cacace
- Center for iPS Cell Research and Application, Kyoto University
- Shigeru Kondo
- Takeda-CiRA Joint program (T-CiRA)
- Yuya Fujiwara
- Center for iPS Cell Research and Application, Kyoto University
- Takeshi Hatani
- Center for iPS Cell Research and Application, Kyoto University
- Masako Sasaki
- Center for iPS Cell Research and Application, Kyoto University
- Yuki Naka
- Center for iPS Cell Research and Application, Kyoto University
- Chikako Okubo
- Center for iPS Cell Research and Application, Kyoto University
- Megumi Narita
- Center for iPS Cell Research and Application, Kyoto University
- Ikue Takei
- Center for iPS Cell Research and Application, Kyoto University
- Stephanie C. Napier
- Takeda-CiRA Joint program (T-CiRA)
- Tsukasa Sugo
- GenAhead Bio Inc.
- Sachiko Imaichi
- Pharmaceutical Science, Takeda Pharmaceutical Company Limited
- Taku Monjo
- IBL, Takeda Pharmaceutical Company Limited
- Tatsuya Ando
- IBL, Takeda Pharmaceutical Company Limited
- Norihisa Tamura
- Takeda-CiRA Joint program (T-CiRA)
- Kenichi Imahashi
- Takeda-CiRA Joint program (T-CiRA)
- Tomoyuki Nishimoto
- Takeda-CiRA Joint program (T-CiRA)
- Yoshinori Yoshida
- Center for iPS Cell Research and Application, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-021-23816-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) suffer from limited maturation. Here the authors identify ERRγ agonist as a factor that enhances cardiac morphological, metabolic, contractile and electrical maturation of hiPSC-derived CMs with T-tubule formation.
