Contribution of white matter hyperintensities to ventricular enlargement in older adults

Angela C.C. Jochems; Susana Muñoz Maniega; Maria del C Valdés Hernández; Gayle Barclay; Devasuda Anblagan; Lucia Ballerini; Rozanna Meijboom; Stewart Wiseman; Adele M. Taylor; Janie Corley; Francesca M. Chappell; Ellen V. Backhouse; Michael S. Stringer; David Alexander Dickie; Mark E. Bastin; Ian J. Deary; Simon R. Cox; Joanna M. Wardlaw

NeuroImage: Clinical (Jan 2022)

Contribution of white matter hyperintensities to ventricular enlargement in older adults

Angela C.C. Jochems,
Susana Muñoz Maniega,
Maria del C Valdés Hernández,
Gayle Barclay,
Devasuda Anblagan,
Lucia Ballerini,
Rozanna Meijboom,
Stewart Wiseman,
Adele M. Taylor,
Janie Corley,
Francesca M. Chappell,
Ellen V. Backhouse,
Michael S. Stringer,
David Alexander Dickie,
Mark E. Bastin,
Ian J. Deary,
Simon R. Cox,
Joanna M. Wardlaw

Affiliations

Angela C.C. Jochems: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
Susana Muñoz Maniega: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK; Lothian Birth Cohorts Group, The University of Edinburgh, UK
Maria del C Valdés Hernández: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK; Lothian Birth Cohorts Group, The University of Edinburgh, UK
Gayle Barclay: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
Devasuda Anblagan: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Lothian Birth Cohorts Group, The University of Edinburgh, UK
Lucia Ballerini: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK; Lothian Birth Cohorts Group, The University of Edinburgh, UK
Rozanna Meijboom: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK; Lothian Birth Cohorts Group, The University of Edinburgh, UK
Stewart Wiseman: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK; Lothian Birth Cohorts Group, The University of Edinburgh, UK
Adele M. Taylor: Lothian Birth Cohorts Group, The University of Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK
Janie Corley: Lothian Birth Cohorts Group, The University of Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK
Francesca M. Chappell: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
Ellen V. Backhouse: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK; Lothian Birth Cohorts Group, The University of Edinburgh, UK
Michael S. Stringer: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK
David Alexander Dickie: Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary & Life Sciences, Queen Elizabeth University Hospital, University of Glasgow, Glasgow, UK
Mark E. Bastin: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; Lothian Birth Cohorts Group, The University of Edinburgh, UK
Ian J. Deary: Lothian Birth Cohorts Group, The University of Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK
Simon R. Cox: Lothian Birth Cohorts Group, The University of Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK
Joanna M. Wardlaw: Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK; UK Dementia Research Institute at the University of Edinburgh, Edinburgh, UK; Lothian Birth Cohorts Group, The University of Edinburgh, UK; Corresponding author at: University of Edinburgh, Chancellor’s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK.

Journal volume & issue: Vol. 34
p. 103019

Abstract

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Lateral ventricles might increase due to generalized tissue loss related to brain atrophy. Alternatively, they may expand into areas of tissue loss related to white matter hyperintensities (WMH).We assessed longitudinal associations between lateral ventricle and WMH volumes, accounting for total brain volume, blood pressure, history of stroke, cardiovascular disease, diabetes and smoking at ages 73, 76 and 79, in participants from the Lothian Birth Cohort 1936, including MRI data from all available time points.Lateral ventricle volume increased steadily with age, WMH volume change was more variable. WMH volume decreased in 20% and increased in remaining subjects. Over 6 years, lateral ventricle volume increased by 3% per year of age, 0.1% per mm Hg increase in blood pressure, 3.2% per 1% decrease of total brain volume, and 4.5% per 1% increase of WMH volume. Over time, lateral ventricle volumes were 19% smaller in women than men.Ventricular and WMH volume changes are modestly associated and independent of general brain atrophy, suggesting that their underlying processes do not fully overlap.

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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