Frontiers in Oncology (Feb 2016)

The significance of a common idiotype (1F7) on antibodies against human immune deficiency virus type 1 and hepatitis C virus

  • Sybille eMuller,
  • Matthew S Parsons,
  • Heinz eKohler,
  • Michael eGrant

DOI
https://doi.org/10.3389/fonc.2016.00011
Journal volume & issue
Vol. 6

Abstract

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In this review, we trace the concept and potential functional role of regulatory idiotypes in the immune response to human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus, and hepatitis C virus (HCV). A major idiotype involved in these viral infections is recognized and defined by a murine monoclonal antibody (1F7). Antibodies expressing the idiotype defined by 1F7 are dominant in HIV-1 infection and are also found on many broadly neutralizing antibodies against HIV-1. This regulatory idiotypic axis offers opportunities for exploitation in vaccine development for HIV-1, HCV and other chronic viral infections.

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