Frontiers in Immunology (Feb 2024)

The integrated bioinformatic analysis identifies immune microenvironment-related potential biomarkers for patients with gestational diabetes mellitus

  • Jie-ling Chen,
  • Hui-fang Dai,
  • Xin-chen Kan,
  • Xin-chen Kan,
  • Jie Wu,
  • Jie Wu,
  • Jie Wu,
  • Hong-Wu Chen,
  • Hong-Wu Chen,
  • Hong-Wu Chen

DOI
https://doi.org/10.3389/fimmu.2024.1296855
Journal volume & issue
Vol. 15

Abstract

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BackgroundGestational diabetes mellitus (GDM), a transient disease, may lead to short- or long-term adverse influences on maternal and fetal health. Therefore, its potential functions, mechanisms and related molecular biomarkers must be comprehended for the control, diagnosis and treatment of GDM.MethodsThe differentially expressed genes (DEGs) were identified using GSE49524 and GSE87295 associated with GDM from the Gene Expression Omnibus database, followed by function enrichment analysis, protein-protein interactions network construction, hub DEGs mining, diagnostic value evaluation and immune infiltration analysis. Finally, hub DEGs, the strongest related to immune infiltration, were screened as immune-related biomarkers.ResultsA hundred and seven DEGs were identified between patients with GDM and healthy individuals. Six hub genes with high diagnostic values, including ALDH1A1, BMP4, EFNB2, MME, PLAUR and SLIT2, were identified. Among these, two immune-related genes (PLAUR and SLIT2) with the highest absolute correlation coefficient were considered immune-related biomarkers in GDM.ConclusionOur study provides a comprehensive analysis of GDM, which would provide a foundation for the development of diagnosis and treatment of GDM.

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