Nature Communications (Aug 2022)

Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation

  • Joana Silva,
  • Ferhat Alkan,
  • Sofia Ramalho,
  • Goda Snieckute,
  • Stefan Prekovic,
  • Ana Krotenberg Garcia,
  • Santiago Hernández-Pérez,
  • Rob van der Kammen,
  • Danielle Barnum,
  • Liesbeth Hoekman,
  • Maarten Altelaar,
  • Wilbert Zwart,
  • Saskia Jacoba Elisabeth Suijkerbuijk,
  • Simon Bekker-Jensen,
  • William James Faller

DOI
https://doi.org/10.1038/s41467-022-32220-4
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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Intestinal stem cells are responsible for replenishing cells within the high-turnover intestinal epithelium. Here they show that ribosome dynamics affect intestinal stem cell identity through a mechanism that is triggered by changes in nutrient availability.