Nuclear Phospholipids and Signaling: An Update of the Story

Abstract

In the last three decades, the presence of phospholipids in the nucleus has been shown and thoroughly investigated. A considerable amount of interest has been raised about nuclear inositol lipids, mainly because of their role in signaling acting. Here, we review the main issues of nuclear phospholipid localization and the role of nuclear inositol lipids and their related enzymes in cellular signaling, both in physiological and pathological conditions.

Keywords

• nucleus
• phosphoinositides
• phospholipases C
• myelodysplastic neoplasms (MDS)
• muscle
• brain