Nature Communications (Dec 2022)

A multi-phenotype analysis reveals 19 susceptibility loci for basal cell carcinoma and 15 for squamous cell carcinoma

  • Mathias Seviiri,
  • Matthew H. Law,
  • Jue-Sheng Ong,
  • Puya Gharahkhani,
  • Pierre Fontanillas,
  • The 23andMe Research Team,
  • Catherine M. Olsen,
  • David C. Whiteman,
  • Stuart MacGregor

DOI
https://doi.org/10.1038/s41467-022-35345-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

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Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common skin cancers and have genetic overlap. Here, the authors use a multi-trait genetic and phenotypic analysis to reveal susceptibility loci for BCC and SCC, and report an optimised polygenic risk score for risk stratification.