Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

Li Zhang; Li Zhang; Li Zhang; Li Zhang; Huachong Xu; Ning Ding; Ning Ding; Xue Li; Xiaoyin Chen; Zhuangfei Chen

doi:10.3389/fphys.2021.715443

Frontiers in Physiology (Nov 2021)

Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

Li Zhang,
Li Zhang,
Li Zhang,
Li Zhang,
Huachong Xu,
Ning Ding,
Ning Ding,
Xue Li,
Xiaoyin Chen,
Zhuangfei Chen

Affiliations

Li Zhang: Key Laboratory of Central CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China
Li Zhang: Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou, China
Li Zhang: Bioland Laboratory, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China
Li Zhang: Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences, Qingdao, China
Huachong Xu: School of Traditional Chinese Medicine, Jinan University, Guangzhou, China
Ning Ding: Key Laboratory of Central CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, China
Ning Ding: Medical College, Kunming University of Science and Technology, Kunming, China
Xue Li: School of Sports Medicine and Health, Chengdu Sport University, Chengdu, China
Xiaoyin Chen: School of Traditional Chinese Medicine, Jinan University, Guangzhou, China
Zhuangfei Chen: Medical College, Kunming University of Science and Technology, Kunming, China

DOI: https://doi.org/10.3389/fphys.2021.715443
Journal volume & issue: Vol. 12

Abstract

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Aging and neurodegenerative diseases are frequently associated with the disruption of the extracellular microenvironment, which includes mesenchyme and body fluid components. Caloric restriction (CR) has been recognized as a lifestyle intervention that can improve long-term health. In addition to preventing metabolic disorders, CR has been shown to improve brain health owing to its enhancing effect on cognitive functions or retarding effect on the progression of neurodegenerative diseases. This article summarizes current findings regarding the neuroprotective effects of CR, which include the modulation of metabolism, autophagy, oxidative stress, and neuroinflammation. This review may offer future perspectives for brain aging interventions.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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Abstract

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