Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication

Tatyana M. Khomenko; Anna A. Shtro; Anastasia V. Galochkina; Yulia V. Nikolaeva; Galina D. Petukhova; Sophia S. Borisevich; Dina V. Korchagina; Konstantin P. Volcho; Nariman F. Salakhutdinov

doi:10.3390/molecules26247493

Molecules (Dec 2021)

Monoterpene-Containing Substituted Coumarins as Inhibitors of Respiratory Syncytial Virus (RSV) Replication

Tatyana M. Khomenko,
Anna A. Shtro,
Anastasia V. Galochkina,
Yulia V. Nikolaeva,
Galina D. Petukhova,
Sophia S. Borisevich,
Dina V. Korchagina,
Konstantin P. Volcho,
Nariman F. Salakhutdinov

Affiliations

Tatyana M. Khomenko: Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia
Anna A. Shtro: Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia
Anastasia V. Galochkina: Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia
Yulia V. Nikolaeva: Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia
Galina D. Petukhova: Laboratory of Chemotherapy for Viral Infections, Smorodintsev Research Intitute of Influenza, Professor Popova Str., 15/17, 197376 St. Petersburg, Russia
Sophia S. Borisevich: Laboratory of Physical Chemistry, Ufa Chemistry Institute of the Ufa Federal Research Center, 71 Octyabrya pr., 450054 Ufa, Russia
Dina V. Korchagina: Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia
Konstantin P. Volcho: Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia
Nariman F. Salakhutdinov: Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Acad. Lavrentjev Ave. 9, 630090 Novosibirsk, Russia

DOI: https://doi.org/10.3390/molecules26247493
Journal volume & issue: Vol. 26, no. 24
p. 7493

Abstract

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Respiratory syncytial virus (RSV) is a critical cause of infant mortality. However, there are no vaccines and adequate drugs for its treatment. We showed, for the first time, that O-linked coumarin–monoterpene conjugates are effective RSV inhibitors. The most potent compounds are active against both RSV serotypes, A and B. According to the results of the time-of-addition experiment, the conjugates act at the early stages of virus cycle. Based on molecular modelling data, RSV F protein may be considered as a possible target.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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