Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma

Harish Potu; Luke F. Peterson; Malathi Kandarpa; Anupama Pal; Hanshi Sun; Alison Durham; Paul W. Harms; Peter C. Hollenhorst; Ugur Eskiocak; Moshe Talpaz; Nicholas J. Donato

doi:10.1038/ncomms14449

Nature Communications (Feb 2017)

Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma

Harish Potu,
Luke F. Peterson,
Malathi Kandarpa,
Anupama Pal,
Hanshi Sun,
Alison Durham,
Paul W. Harms,
Peter C. Hollenhorst,
Ugur Eskiocak,
Moshe Talpaz,
Nicholas J. Donato

Affiliations

Harish Potu: Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center
Luke F. Peterson: Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center
Malathi Kandarpa: Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center
Anupama Pal: Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center
Hanshi Sun: Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry
Alison Durham: Department of Dermatology, University of Michigan School of Medicine
Paul W. Harms: Departments of Pathology and Dermatology, University of Michigan School of Medicine
Peter C. Hollenhorst: Department of Biochemistry and Molecular Biology, Medical Sciences Program, Indiana University Bloomington
Ugur Eskiocak: Children’s Research Institute and Department of Pediatrics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center
Moshe Talpaz: Department of Internal Medicine/Division of Hematology/Oncology, University of Michigan School of Medicine and Comprehensive Cancer Center
Nicholas J. Donato: Department of Pharmacology, University of Michigan School of Medicine

DOI: https://doi.org/10.1038/ncomms14449
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Usp9x is a deubiquitinating enzyme with altered expression in melanoma; however its functional contribution in this context is not clear. Here the authors show that Usp9x regulates the stability of the transcription factor Ets-1 that in turn impacts metastatic melanoma through increased expression of NRAS.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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