Cell shape information is transduced through tension-independent mechanisms

Amit Ron; Evren U. Azeloglu; Rhodora C. Calizo; Mufeng Hu; Smiti Bhattacharya; Yibang Chen; Gomathi Jayaraman; Sunwoo Lee; Susana R. Neves-Zaph; Hong Li; Ronald E. Gordon; John C. He; James C. Hone; Ravi Iyengar

doi:10.1038/s41467-017-02218-4

Nature Communications (Dec 2017)

Cell shape information is transduced through tension-independent mechanisms

Amit Ron,
Evren U. Azeloglu,
Rhodora C. Calizo,
Mufeng Hu,
Smiti Bhattacharya,
Yibang Chen,
Gomathi Jayaraman,
Sunwoo Lee,
Susana R. Neves-Zaph,
Hong Li,
Ronald E. Gordon,
John C. He,
James C. Hone,
Ravi Iyengar

Affiliations

Amit Ron: Department of Mechanical Engineering, Columbia University
Evren U. Azeloglu: Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
Rhodora C. Calizo: Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
Mufeng Hu: Department of Mechanical Engineering, Columbia University
Smiti Bhattacharya: Department of Mechanical Engineering, Columbia University
Yibang Chen: Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
Gomathi Jayaraman: Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
Sunwoo Lee: School of Electrical and Computer Engineering, Cornell University
Susana R. Neves-Zaph: Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
Hong Li: Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University – New Jersey Medical School
Ronald E. Gordon: Department of Pathology, Icahn School of Medicine at Mount Sinai
John C. He: Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai
James C. Hone: Department of Mechanical Engineering, Columbia University
Ravi Iyengar: Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-017-02218-4
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

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It is not known whether the shape of a cell can regulate cellular phenotype independently. Here, the authors show that culturing kidney podocytes or smooth muscle cells on 3-D biomimetic surfaces results in phenotypic changes and that cell shape is sensed by integrin β3 in a tension-independent manner.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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