Nature Communications (Aug 2021)
Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment
- Hua Sun,
- Song Cao,
- R. Jay Mashl,
- Chia-Kuei Mo,
- Simone Zaccaria,
- Michael C. Wendl,
- Sherri R. Davies,
- Matthew H. Bailey,
- Tina M. Primeau,
- Jeremy Hoog,
- Jacqueline L. Mudd,
- Dennis A. Dean,
- Rajesh Patidar,
- Li Chen,
- Matthew A. Wyczalkowski,
- Reyka G. Jayasinghe,
- Fernanda Martins Rodrigues,
- Nadezhda V. Terekhanova,
- Yize Li,
- Kian-Huat Lim,
- Andrea Wang-Gillam,
- Brian A. Van Tine,
- Cynthia X. Ma,
- Rebecca Aft,
- Katherine C. Fuh,
- Julie K. Schwarz,
- Jose P. Zevallos,
- Sidharth V. Puram,
- John F. Dipersio,
- The NCI PDXNet Consortium,
- Brandi Davis-Dusenbery,
- Matthew J. Ellis,
- Michael T. Lewis,
- Michael A. Davies,
- Meenhard Herlyn,
- Bingliang Fang,
- Jack A. Roth,
- Alana L. Welm,
- Bryan E. Welm,
- Funda Meric-Bernstam,
- Feng Chen,
- Ryan C. Fields,
- Shunqiang Li,
- Ramaswamy Govindan,
- James H. Doroshow,
- Jeffrey A. Moscow,
- Yvonne A. Evrard,
- Jeffrey H. Chuang,
- Benjamin J. Raphael,
- Li Ding
Affiliations
- Hua Sun
- Department of Medicine, Washington University in St. Louis
- Song Cao
- Department of Medicine, Washington University in St. Louis
- R. Jay Mashl
- Department of Medicine, Washington University in St. Louis
- Chia-Kuei Mo
- Department of Medicine, Washington University in St. Louis
- Simone Zaccaria
- Department of Computer Science, Princeton University
- Michael C. Wendl
- McDonnell Genome Institute, Washington University in St. Louis
- Sherri R. Davies
- Department of Medicine, Washington University in St. Louis
- Matthew H. Bailey
- Huntsman Cancer Institute, University of Utah
- Tina M. Primeau
- Department of Medicine, Washington University in St. Louis
- Jeremy Hoog
- Department of Medicine, Washington University in St. Louis
- Jacqueline L. Mudd
- Department of Medicine, Washington University in St. Louis
- Dennis A. Dean
- Seven Bridges Genomics, Inc., Cambridge
- Rajesh Patidar
- Frederick National Laboratory for Cancer Research
- Li Chen
- Frederick National Laboratory for Cancer Research
- Matthew A. Wyczalkowski
- Department of Medicine, Washington University in St. Louis
- Reyka G. Jayasinghe
- Department of Medicine, Washington University in St. Louis
- Fernanda Martins Rodrigues
- Department of Medicine, Washington University in St. Louis
- Nadezhda V. Terekhanova
- Department of Medicine, Washington University in St. Louis
- Yize Li
- Department of Medicine, Washington University in St. Louis
- Kian-Huat Lim
- Department of Medicine, Washington University in St. Louis
- Andrea Wang-Gillam
- Department of Medicine, Washington University in St. Louis
- Brian A. Van Tine
- Department of Medicine, Washington University in St. Louis
- Cynthia X. Ma
- Department of Medicine, Washington University in St. Louis
- Rebecca Aft
- Siteman Cancer Center, Washington University in St. Louis
- Katherine C. Fuh
- Department of Medicine, Washington University in St. Louis
- Julie K. Schwarz
- Siteman Cancer Center, Washington University in St. Louis
- Jose P. Zevallos
- Siteman Cancer Center, Washington University in St. Louis
- Sidharth V. Puram
- Siteman Cancer Center, Washington University in St. Louis
- John F. Dipersio
- Department of Medicine, Washington University in St. Louis
- The NCI PDXNet Consortium
- Brandi Davis-Dusenbery
- Seven Bridges Genomics, Inc., Cambridge
- Matthew J. Ellis
- Lester and Sue Smith Breast Center, Baylor College of Medicine
- Michael T. Lewis
- Lester and Sue Smith Breast Center, Baylor College of Medicine
- Michael A. Davies
- The University of Texas MD Anderson Cancer Center
- Meenhard Herlyn
- The Wistar Institute
- Bingliang Fang
- The University of Texas MD Anderson Cancer Center
- Jack A. Roth
- The University of Texas MD Anderson Cancer Center
- Alana L. Welm
- Huntsman Cancer Institute, University of Utah
- Bryan E. Welm
- Huntsman Cancer Institute, University of Utah
- Funda Meric-Bernstam
- The University of Texas MD Anderson Cancer Center
- Feng Chen
- Department of Medicine, Washington University in St. Louis
- Ryan C. Fields
- Siteman Cancer Center, Washington University in St. Louis
- Shunqiang Li
- Department of Medicine, Washington University in St. Louis
- Ramaswamy Govindan
- Department of Medicine, Washington University in St. Louis
- James H. Doroshow
- Division of Cancer Treatment and Diagnosis, National Cancer Institute
- Jeffrey A. Moscow
- Investigational Drug Branch, National Cancer Institute
- Yvonne A. Evrard
- Frederick National Laboratory for Cancer Research
- Jeffrey H. Chuang
- The Jackson Laboratory for Genomic Medicine
- Benjamin J. Raphael
- Department of Computer Science, Princeton University
- Li Ding
- Department of Medicine, Washington University in St. Louis
- DOI
- https://doi.org/10.1038/s41467-021-25177-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Patient-derived xenograft models (PDX) have been extensively used to study the molecular and clinical features of cancers. Here the authors present a cohort of 536 PDX models from 25 cancers, as well as their genomic and evolutionary profiles and their suitability for clinical trials.
