Tumor suppression by control of matrix metalloproteinase recycling

Abstract

Secretion of matrix metalloproteinases (MMPs) enables cancer cells to degrade extracellular matrix, thus promoting tumor invasion and metastasis. We have recently found that the endosomal protein WDFY2 serves as a gatekeeper for MMP recycling from endosomes and that deletion of WDFY2, which is frequently lost in metastatic cancers, causes increased matrix degradation and cell invasion.

Keywords

• endocytosis
• invasion
• metalloproteinase
• metastasis
• tumor suppressor