Integration of tri-polar microelectrodes for performance enhancement of an impedance biosensor

Sameh Sherif; Omar E. Morsy; Laila Ziko; Rania Siam; Yehya H. Ghallab; Yehea Ismail

Sensing and Bio-Sensing Research (Jun 2020)

Integration of tri-polar microelectrodes for performance enhancement of an impedance biosensor

Sameh Sherif,
Omar E. Morsy,
Laila Ziko,
Rania Siam,
Yehya H. Ghallab,
Yehea Ismail

Affiliations

Sameh Sherif: Biomedical Engineering Department, Helwan University, Cairo, Egypt, Center of Nanoelectronics and Devices (CND), Zewail City of Science and Technology, The American University in Cairo (AUC), Cairo, Egypt; Corresponding author.
Omar E. Morsy: Department of Electronics and Communication Engineering, Misr International University, Cairo, Egypt, Center of Nanoelectronics and Devices (CND) at Zewail City for Science and Technology, The American University in Cairo (AUC), Cairo, Egypt
Laila Ziko: Graduate Program of Biotechnology, School of Sciences and Engineering, American University in Cairo (AUC), Cairo, Egypt
Rania Siam: Biology Department, School of Sciences and Engineering, American University in Cairo (AUC), Cairo, Egypt, University of Medicine and Health Sciences, Saint Kitts and Nevis
Yehya H. Ghallab: Electronics and Communication Department, Kuwait College of Science and Technology, Kuwait, Biomedical Engineering Department, Helwan University, Cairo, Egypt, Center of Nano electronics and Devices (CND), Zewail City of Science and Technology, The American University in Cairo (AUC), Cairo, Egypt
Yehea Ismail: Center of Nano electronics and Devices (CND), Zewail City of Science and Technology, The American University in Cairo (AUC), Cairo, Egypt

Journal volume & issue: Vol. 28

Abstract

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This paper demonstrates the effect of microelectrodes configuration on the sensitivity and accuracy of the micro-electrical impedance spectroscopy (μEIS). Bi-polar and tri-polar microelectrodes configurations were presented, fabricated and experimentally used to extract the electrical parameters of Human Bone Osteosarcoma Epithelial (U2OS) viable and dead cells. A comparison between the experimental results are presented and discussed. These experimental results show that the tri-polar electrode configuration has higher sensitivity compared to bi-polar configuration. Keywords: Bio impedance, U2OS cells, μEIS, Microfluidic platform

Published in Sensing and Bio-Sensing Research

ISSN: 2214-1804 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Engineering (General). Civil engineering (General)
Website: http://www.journals.elsevier.com/sensing-and-bio-sensing-research/

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