Radiology and Oncology (Dec 2022)

Detection and localization of hyperfunctioning parathyroid glands on [18F]fluorocholine PET/ CT using deep learning – model performance and comparison to human experts

  • Jarabek Leon,
  • Jamsek Jan,
  • Cuderman Anka,
  • Rep Sebastijan,
  • Hocevar Marko,
  • Kocjan Tomaz,
  • Jensterle Mojca,
  • Spiclin Ziga,
  • Macek Lezaic Ziga,
  • Cvetko Filip,
  • Lezaic Luka

DOI
https://doi.org/10.2478/raon-2022-0037
Journal volume & issue
Vol. 56, no. 4
pp. 440 – 452

Abstract

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In the setting of primary hyperparathyroidism (PHPT), [18F]fluorocholine PET/CT (FCH-PET) has excellent diagnostic performance, with experienced practitioners achieving 97.7% accuracy in localising hyperfunctioning parathyroid tissue (HPTT). Due to the relative triviality of the task for human readers, we explored the performance of deep learning (DL) methods for HPTT detection and localisation on FCH-PET images in the setting of PHPT.

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