An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase

Chu-Ya Wu; I-Chen Hu; Yi-Chen Yang; Wei-Cheng Ding; Chih-Hsuan Lai; Yi-Zong Lee; Yi-Chung Liu; Hui-Chun Cheng; Ping-Chiang Lyu

doi:10.1038/s42003-020-01177-9

Communications Biology (Aug 2020)

An essential role of acetyl coenzyme A in the catalytic cycle of insect arylalkylamine N-acetyltransferase

Chu-Ya Wu,
I-Chen Hu,
Yi-Chen Yang,
Wei-Cheng Ding,
Chih-Hsuan Lai,
Yi-Zong Lee,
Yi-Chung Liu,
Hui-Chun Cheng,
Ping-Chiang Lyu

Affiliations

Chu-Ya Wu: Institute of Bioinformatics and Structural Biology, National Tsing Hua University
I-Chen Hu: Institute of Bioinformatics and Structural Biology, National Tsing Hua University
Yi-Chen Yang: Institute of Bioinformatics and Structural Biology, National Tsing Hua University
Wei-Cheng Ding: Institute of Bioinformatics and Structural Biology, National Tsing Hua University
Chih-Hsuan Lai: Institute of Bioinformatics and Structural Biology, National Tsing Hua University
Yi-Zong Lee: Institute of Bioinformatics and Structural Biology, National Tsing Hua University
Yi-Chung Liu: Institute of Population Sciences, National Health Research Institutes
Hui-Chun Cheng: Institute of Bioinformatics and Structural Biology, National Tsing Hua University
Ping-Chiang Lyu: Institute of Bioinformatics and Structural Biology, National Tsing Hua University

DOI: https://doi.org/10.1038/s42003-020-01177-9
Journal volume & issue: Vol. 3, no. 1
pp. 1 – 12

Abstract

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Wu et al. provide insight to the role of acetyl coenzyme A in regulating N-acetylation in insect AANAT using ITC and NMR methods. These results provide useful data on the structural function of insect AANATs.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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