The effect of new amino acid derivatives of 1,4-naphthoquinone on the Na+, K+-АТPase activity of loach embryos in vitro

Abstract

The effect of amino acid derivatives of 1,4-naphtoquinone on the loach embryos Na+, K+-activated Mg2+-dependent ATPase in vitro during the early stages of embryo­genesis was investigated. We analysed the effect different concentrations of derivatives on the enzymatic activity of Na+, K+-pump with the half-inhibition constants (І50) during the synchronous blastomer divisions. It has been shown, that effect possatium salts N-(2-chlorine-1,4-naphtoquinone-3)-alanine and histidine lead to changes of activity of membrane enzyme of embryos on the stage of 10 division. Thus, amino acid derivatives of 1,4-naphtoquinone might be considered as dose-dependent modulators of Na+, K+-activated Mg2+-dependent hydrolysis of ATP membrane vesicules.

Keywords

• potassium salts n-(2-chlorine-1
• 4-naphtoquinone-3)-alanine and his­ti­dine
• na+
• k+-атpase
• loach embryos
• blastomer divisions