Nature Communications (May 2022)
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
- Mona Hoseini Soflaee,
- Rushendhiran Kesavan,
- Umakant Sahu,
- Alpaslan Tasdogan,
- Elodie Villa,
- Zied Djabari,
- Feng Cai,
- Diem H. Tran,
- Hieu S. Vu,
- Eunus S. Ali,
- Halie Rion,
- Brendan P. O’Hara,
- Sherwin Kelekar,
- James Hughes Hallett,
- Misty Martin,
- Thomas P. Mathews,
- Peng Gao,
- John M. Asara,
- Brendan D. Manning,
- Issam Ben-Sahra,
- Gerta Hoxhaj
Affiliations
- Mona Hoseini Soflaee
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Rushendhiran Kesavan
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Umakant Sahu
- Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
- Alpaslan Tasdogan
- Department of Dermatology, University Hospital Essen & German Cancer Consortium, Partner Site
- Elodie Villa
- Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
- Zied Djabari
- Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
- Feng Cai
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Diem H. Tran
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Hieu S. Vu
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Eunus S. Ali
- Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
- Halie Rion
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Brendan P. O’Hara
- Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
- Sherwin Kelekar
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- James Hughes Hallett
- Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health
- Misty Martin
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Thomas P. Mathews
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- Peng Gao
- Metabolomics Core Facility, Robert H. Lurie Comprehensive Cancer Center, Northwestern University
- John M. Asara
- Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School
- Brendan D. Manning
- Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health
- Issam Ben-Sahra
- Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University
- Gerta Hoxhaj
- Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-30362-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Nucleotides are essential for different biological processes and have been also associated to cancer development. Depleting cellular nucleotides is a strategy commonly employed to target cancers. Here, the authors show that purine depletion induces serine synthesis to promote cancer cell migration and metastasis.
