2-Phenethylamines in Medicinal Chemistry: A Review

Carlos T. Nieto; Alejandro Manchado; Leland Belda; David Diez; Narciso M. Garrido

doi:10.3390/molecules28020855

Molecules (Jan 2023)

2-Phenethylamines in Medicinal Chemistry: A Review

Carlos T. Nieto,
Alejandro Manchado,
Leland Belda,
David Diez,
Narciso M. Garrido

Affiliations

Carlos T. Nieto: Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, Pl. Caídos, s/n, 37008 Salamanca, Spain
Alejandro Manchado: Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, Pl. Caídos, s/n, 37008 Salamanca, Spain
Leland Belda: Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, Pl. Caídos, s/n, 37008 Salamanca, Spain
David Diez: Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, Pl. Caídos, s/n, 37008 Salamanca, Spain
Narciso M. Garrido: Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, Pl. Caídos, s/n, 37008 Salamanca, Spain

DOI: https://doi.org/10.3390/molecules28020855
Journal volume & issue: Vol. 28, no. 2
p. 855

Abstract

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A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and appealing screening compounds. Latest reports in discovering new bioactive 2-phenethylamines by research groups are covered too.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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Abstract

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