Педиатрическая фармакология (Mar 2010)

STUDIES OF SAFETY AND FUNCTIONAL AND METABOLIC EFFECTS OF NON-IONIC CONTRAST MEDIA IN CHILDREN WITH NEPHROPATHIES

  • E.N. Tsygina,
  • I.E. Smirnov,
  • A.G. Kucherenko,
  • G.F. Zadkova,
  • O.F. Lukina,
  • O.O. Kupriyanova,
  • T.E. Sorokina,
  • M.I. Bakanov,
  • S.N. Zorkin,
  • S.P. Yatsyk,
  • A.N. Tsygin

Journal volume & issue
Vol. 7, no. 2
pp. 78 – 82

Abstract

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A study was conducted to assess the safety of non-ionic contrast media in paediatric nephrourology and their impact onto renal function and homeostasis, reflecting the risk of development of contrast-induced nephropathy. After contrast media use we observed elevation of cystatin C and endothelin, decrease of sodium fractional excretion and hypocoagulation were identified. The results obtained indicate that renal hypoperfusion with a consequent decrease of sodium fractional excretion and elevation of endothelin production may play a role in contrast-induced nephropathy. Increased serum cystatin C reflects adverse impact of contrast agents on renal function. Hypocoagulation effect requires that coagulation disorders must be excluded before use of contast media.Key words: children, contrast-induced nephropathy, renal function, cystatin C, endothelin, hemostasis. (Pediatric Pharmacology. – 2010; 7(2):78-82)