Lesions of skin and mucous membranes of female genital organs associated with human papillomavirus. Local treatment options

Abstract

Lesions of skin and mucous membranes of female genital organs associated with human papillomavirus. Local treatment options Yu.E. Dobrokhotova1, L.V. Saprykina1, O.A. Saprykina2 1 Pirogov Russian National Research Medical University, Moscow, Russian Federation 2 Medical center “Vrachevatel”, Moscow reg., Pushkino, Russian Federation Human papillomavirus (HPV) is the most common sexually transmitted infection. HPV (Papillomaviridae family) is a non-enveloped virus, which contains a double-stranded DNA and induces lesions of the skin and mucous membranes. The clinical manifestations of НPV-infection depend on multiple factors including the viral genotype, the genotype of the host, the type of epithelium infected and environmental factors such as the status of host immunity and nutritional factors. Primary prevention of HPV infection is possible with the help of vaccination against HPV, but the level of vaccination in a number of countries, including Russia, remains low. Depending on the manifestations of papillomavirus infection on the genitals, latent, subclinical and clinical forms are distinguished. Anogenital warts (AW) are the most common form of HPV-infections. AW are benign proliferative lesions caused by HPV types 6 and 11. Diagnostics of AW is usually based on clinical data. During pregnancy, active proliferation of the AW is possible. The purpose of AW therapy is lesions destruction. Chemical, cytotoxic and physical methods of AW destruction are applied. Methods of AW destruction are chemical methods, cytotoxic methods, physical methods. Local therapy with activated glycyrrhizic acid for pre- and postoperative preparation is warranted. Key words: human papillomavirus, HPV, condyloma acuminatum, anogenital warts, treatment, destruction, diagnosis, pregnancy, activated glycyrrhizic acid, antiviral and immunostimulatory activity. For citation: Dobrokhotova Yu.E., Saprykina L.V., Saprykina O.A. Lesions of skin and mucous membranes of female genital organs associated with human papillomavirus. Local treatment options. Russian journal of Woman and Child Health. 2018;1(1):57–61.