STUDY OF PROTECTIVE ACTIVITY OF PROTEIN-CONTAINING ANTIGENS OF STREPTOCOCCUS PNEUMONIAE IN A HETEROLOGOUS SYSTEM

Abstract

Aim. Study protective activity of protein-containing antigens of pneumococcus, obtained from serotypes 6В, 10А, 14, 19F, 23F and 36R, against infection with heterologous strains of S. pneumoniae. Materials and methods. S. pneumoniae strains of serotypes 3, 6В, 10А, 14, 19F, 23F and 36R, obtained from the collection of pneumococcus strains of Mechnikov RIVS, were used in the study. Protein-containing antigens of S. pneumoniae were isolated by acetone precipitations of supernatant fraction of culture medium. Protective activity of preparations of protein-containing antigens of pneumococcus was studied in experiments of active protection of BALb/c line mice. Results. The data obtained give evidence, that protein-containing antigens of pneumococcus, isolated from serotypes 6В, 10А, 14, 19F and 23F, effectively protect animals from subsequent infection with a heterologous S. pneumoniae strain of serotype 3 No. 11/56. Protection was noted at a level from 80 to 100% (p

Keywords

• s. pneumoniae
• protective activity
• protein-containing antigens