Nature Communications (Jan 2020)
Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy
- Hayley C. Affronti,
- Aryn M. Rowsam,
- Anthony J. Pellerite,
- Spencer R. Rosario,
- Mark D. Long,
- Justine J. Jacobi,
- Anna Bianchi-Smiraglia,
- Christoph S. Boerlin,
- Bryan M. Gillard,
- Ellen Karasik,
- Barbara A. Foster,
- Michael Moser,
- John H. Wilton,
- Kristopher Attwood,
- Mikhail A. Nikiforov,
- Gissou Azabdaftari,
- Roberto Pili,
- James G. Phillips,
- Robert A. Casero,
- Dominic J. Smiraglia
Affiliations
- Hayley C. Affronti
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- Aryn M. Rowsam
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- Anthony J. Pellerite
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- Spencer R. Rosario
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- Mark D. Long
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- Justine J. Jacobi
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- Anna Bianchi-Smiraglia
- Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center
- Christoph S. Boerlin
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- Bryan M. Gillard
- Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center
- Ellen Karasik
- Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center
- Barbara A. Foster
- Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center
- Michael Moser
- Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center
- John H. Wilton
- Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center
- Kristopher Attwood
- Department of Biostatistics, Roswell Park Comprehensive Cancer Center
- Mikhail A. Nikiforov
- Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center
- Gissou Azabdaftari
- Department of Pathology, Roswell Park Comprehensive Cancer Center
- Roberto Pili
- Department of Hematology and Oncology, Indiana University
- James G. Phillips
- Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic
- Robert A. Casero
- The Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins University
- Dominic J. Smiraglia
- Department of Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center
- DOI
- https://doi.org/10.1038/s41467-019-13950-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Prostate cancer cells depend on MTAP, the rate-limiting enzyme involved in the methionine salvage pathway, to cope with increased polyamine biosynthesis. Here, the authors show that inducing upregulation of polyamine biosynthesis and targeting MTAP synergize to increase apoptosis in prostate cancer cells.
