Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

Hirotake Furihata; Satoshi Yamanaka; Toshiaki Honda; Yumiko Miyauchi; Atsuko Asano; Norio Shibata; Masaru Tanokura; Tatsuya Sawasaki; Takuya Miyakawa

doi:10.1038/s41467-020-18488-4

Nature Communications (Sep 2020)

Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

Hirotake Furihata,
Satoshi Yamanaka,
Toshiaki Honda,
Yumiko Miyauchi,
Atsuko Asano,
Norio Shibata,
Masaru Tanokura,
Tatsuya Sawasaki,
Takuya Miyakawa

Affiliations

Hirotake Furihata: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Satoshi Yamanaka: Proteo-Science Center, Ehime University
Toshiaki Honda: Department of Nanopharmaceutical Sciences and Department of Life Science and Applied Chemistry, Nagoya Institute of Technology
Yumiko Miyauchi: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Atsuko Asano: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Norio Shibata: Department of Nanopharmaceutical Sciences and Department of Life Science and Applied Chemistry, Nagoya Institute of Technology
Masaru Tanokura: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Tatsuya Sawasaki: Proteo-Science Center, Ehime University
Takuya Miyakawa: Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

DOI: https://doi.org/10.1038/s41467-020-18488-4
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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5-hydroxythalidomide is a primary thalidomide metabolite generated by the cytochrome P450 isozymes. The reported data, including crystal structure of the 5-hydroxythalidomide-mediated complex of CRBN with SALL4, elucidate how additional hydroxy group of the metabolite enhances the interaction of CRBN with the neosubstrate SALL4.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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