Nature Communications (Sep 2018)
Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation
- René Luijk,
- Haoyu Wu,
- Cavin K Ward-Caviness,
- Eilis Hannon,
- Elena Carnero-Montoro,
- Josine L. Min,
- Pooja Mandaviya,
- Martina Müller-Nurasyid,
- Hailiang Mei,
- Silvere M. van der Maarel,
- BIOS Consortium,
- Caroline Relton,
- Jonathan Mill,
- Melanie Waldenberger,
- Jordana T. Bell,
- Rick Jansen,
- Alexandra Zhernakova,
- Lude Franke,
- Peter A. C. ‘t Hoen,
- Dorret I. Boomsma,
- Cornelia M. van Duijn,
- Marleen M. J. van Greevenbroek,
- Jan H. Veldink,
- Cisca Wijmenga,
- Joyce van Meurs,
- Lucia Daxinger,
- P. Eline Slagboom,
- Erik W. van Zwet,
- Bastiaan T. Heijmans
Affiliations
- René Luijk
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- Haoyu Wu
- Department of Human Genetics, Leiden University Medical Center
- Cavin K Ward-Caviness
- Institute of Epidemiology II, Helmholtz Zentrum München
- Eilis Hannon
- University of Exeter Medical School
- Elena Carnero-Montoro
- Department of Twin Research & Genetic Epidemiology, King’s College London
- Josine L. Min
- MRC Integrative Epidemiology Unit, University of Bristol
- Pooja Mandaviya
- Department of Internal Medicine, Erasmus University Medical Center
- Martina Müller-Nurasyid
- DZHK (German Centre for Cardiovascular Research), partner site: Munich Heart Alliance
- Hailiang Mei
- Department of Human Genetics, Leiden University Medical Center
- Silvere M. van der Maarel
- Department of Human Genetics, Leiden University Medical Center
- BIOS Consortium
- Caroline Relton
- MRC Integrative Epidemiology Unit, University of Bristol
- Jonathan Mill
- University of Exeter Medical School
- Melanie Waldenberger
- Institute of Epidemiology II, Helmholtz Zentrum München
- Jordana T. Bell
- Department of Twin Research & Genetic Epidemiology, King’s College London
- Rick Jansen
- Department of Psychiatry, VU University Medical Center, Neuroscience Campus Amsterdam
- Alexandra Zhernakova
- Department of Genetics, University of Groningen, University Medical Centre Groningen
- Lude Franke
- Department of Genetics, University of Groningen, University Medical Centre Groningen
- Peter A. C. ‘t Hoen
- Department of Human Genetics, Leiden University Medical Center
- Dorret I. Boomsma
- Department of Biological Psychology, Vrije Universiteit Amsterdam, Neuroscience Campus Amsterdam
- Cornelia M. van Duijn
- Department of Epidemiology, Genetic Epidemiology Unit, ErasmusMC
- Marleen M. J. van Greevenbroek
- Department of Internal Medicine, Maastricht University Medical Center
- Jan H. Veldink
- Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht
- Cisca Wijmenga
- Department of Genetics, University of Groningen, University Medical Centre Groningen
- Joyce van Meurs
- Department of Internal Medicine, Erasmus University Medical Center
- Lucia Daxinger
- Department of Human Genetics, Leiden University Medical Center
- P. Eline Slagboom
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- Erik W. van Zwet
- Medical Statistics, Department of Biomedical Data Sciences, Leiden University Medical Center
- Bastiaan T. Heijmans
- Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-05714-3
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
DNA methylation is critically involved in X chromosome inactivation (XCI) and dosage compensation, yet some X-chromosomal genes escape XCI. Here, Lujik et al. identify three autosomal genetic loci that associate with differential DNA methylation near genes that variably escape XCI in females.
