Adaptive evolution of complex innovations through stepwise metabolic niche expansion

Balázs Szappanos; Jonathan Fritzemeier; Bálint Csörgő; Viktória Lázár; Xiaowen Lu; Gergely Fekete; Balázs Bálint; Róbert Herczeg; István Nagy; Richard A. Notebaart; Martin J. Lercher; Csaba Pál; Balázs Papp

doi:10.1038/ncomms11607

Nature Communications (May 2016)

Adaptive evolution of complex innovations through stepwise metabolic niche expansion

Balázs Szappanos,
Jonathan Fritzemeier,
Bálint Csörgő,
Viktória Lázár,
Xiaowen Lu,
Gergely Fekete,
Balázs Bálint,
Róbert Herczeg,
István Nagy,
Richard A. Notebaart,
Martin J. Lercher,
Csaba Pál,
Balázs Papp

Affiliations

Balázs Szappanos: Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences
Jonathan Fritzemeier: Department for Computer Science, Heinrich Heine University, Universitätsstraße 1
Bálint Csörgő: Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences
Viktória Lázár: Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences
Xiaowen Lu: Department of Bioinformatics (CMBI), Radboud University Medical Centre
Gergely Fekete: Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences
Balázs Bálint: SeqOmics Biotechnology Ltd
Róbert Herczeg: SeqOmics Biotechnology Ltd
István Nagy: SeqOmics Biotechnology Ltd
Richard A. Notebaart: Department of Bioinformatics (CMBI), Radboud University Medical Centre
Martin J. Lercher: Department for Computer Science, Heinrich Heine University, Universitätsstraße 1
Csaba Pál: Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences
Balázs Papp: Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences

DOI: https://doi.org/10.1038/ncomms11607
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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A fundamental question in evolutionary biology is how complex innovations requiring multiple genetic changes arise. Here the authors provide lines of evidence that changing environments facilitate the adaptive evolution of complex metabolic innovations via stepwise acquisition of single reactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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