Characterisation of the T-cell response to Ebola virus glycoprotein amongst survivors of the 2013–16 West Africa epidemic

T. R. W. Tipton; Y. Hall; J. A. Bore; A. White; L. S. Sibley; C. Sarfas; Y. Yuki; M. Martin; S. Longet; J. Mellors; K. Ewer; S. Günther; M. Carrington; M. K. Kondé; M. W. Carroll

doi:10.1038/s41467-021-21411-0

Nature Communications (Feb 2021)

Characterisation of the T-cell response to Ebola virus glycoprotein amongst survivors of the 2013–16 West Africa epidemic

T. R. W. Tipton,
Y. Hall,
J. A. Bore,
A. White,
L. S. Sibley,
C. Sarfas,
Y. Yuki,
M. Martin,
S. Longet,
J. Mellors,
K. Ewer,
S. Günther,
M. Carrington,
M. K. Kondé,
M. W. Carroll

Affiliations

T. R. W. Tipton: National Infection Service, Public Health England
Y. Hall: National Infection Service, Public Health England
J. A. Bore: Center for Training and Research on Priority Diseases including Malaria in Guinea (CEFORPAG)
A. White: National Infection Service, Public Health England
L. S. Sibley: National Infection Service, Public Health England
C. Sarfas: National Infection Service, Public Health England
Y. Yuki: Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute
M. Martin: Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute
S. Longet: National Infection Service, Public Health England
J. Mellors: National Infection Service, Public Health England
K. Ewer: The Jenner Institute
S. Günther: Bernhard Nocht Institute for Tropical Medicine
M. Carrington: Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute
M. K. Kondé: Center for Training and Research on Priority Diseases including Malaria in Guinea (CEFORPAG)
M. W. Carroll: National Infection Service, Public Health England

DOI: https://doi.org/10.1038/s41467-021-21411-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 9

Abstract

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T cell responses are known to be essential in the immune response to Ebola virus infection, and the viral glycoprotein is a major antigenic target. Here the authors provide fine detail mapping of T cell antigens and their characterisation in Ebola virus survivor patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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