Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

Magdalena Wagner; Masahito Yoshihara; Iyadh Douagi; Anastasios Damdimopoulos; Sarita Panula; Sophie Petropoulos; Haojiang Lu; Karin Pettersson; Kerstin Palm; Shintaro Katayama; Outi Hovatta; Juha Kere; Fredrik Lanner; Pauliina Damdimopoulou

doi:10.1038/s41467-020-14936-3

Nature Communications (Mar 2020)

Single-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells

Magdalena Wagner,
Masahito Yoshihara,
Iyadh Douagi,
Anastasios Damdimopoulos,
Sarita Panula,
Sophie Petropoulos,
Haojiang Lu,
Karin Pettersson,
Kerstin Palm,
Shintaro Katayama,
Outi Hovatta,
Juha Kere,
Fredrik Lanner,
Pauliina Damdimopoulou

Affiliations

Magdalena Wagner: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital
Masahito Yoshihara: Department of Biosciences and Nutrition, Karolinska Institutet
Iyadh Douagi: Center of Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet
Anastasios Damdimopoulos: Bioinformatics and Expression Analysis core facility, Karolinska Institutet
Sarita Panula: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital
Sophie Petropoulos: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital
Haojiang Lu: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital
Karin Pettersson: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital
Kerstin Palm: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital
Shintaro Katayama: Department of Biosciences and Nutrition, Karolinska Institutet
Outi Hovatta: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital
Juha Kere: Department of Biosciences and Nutrition, Karolinska Institutet
Fredrik Lanner: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital
Pauliina Damdimopoulou: Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet and Karolinska University Hospital

DOI: https://doi.org/10.1038/s41467-020-14936-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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The outer lining or cortex of the human ovary determines fertility and has been postulated to contain oogonial stem cells. Here, the authors generate a single-cell map of the adult human ovarian cortex and show that DDX4 labels perivascular cells but no oogonial stem cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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