Latin American anaphylaxis registry

Edgardo J. Jares, MD; Victoria Cardona, MD, PHD; R. Maximiliano Gómez, MD, PHD; Jonathan A. Bernstein, M.D; Nelson A. Rosario Filho, MD; Ivan Cherrez-Ojeda, MD, MSC; Luis Felipe Ensina, MD PHD; Alicia De Falco, MD; María C. Díaz, MD; Pierre A. Chávez Vereau, MD; Mara M. Rocha Felix, MD, PHD; Jorge Lavrut, MD; Oscar I. Moreno Laflor, MD; Patricia Latour Staffeld, MD; Pedro Piraino, MD; Perla Alacaraz Duarte, MD; Juan C. Ivancevich, MD; Fabian Dabove, MD; Pedro Giavina-Bianchi, MD; Iván O. Tinoco Moran, MD; Fabiana A. Nunes Oliviera, MD; Silvana Monsell, MD; María V. Souza, MD; Alfonso M. Cepeda, MD; Pablo D. Slullitel, MD; Blanca M. Morfin-Maciel, MD

World Allergy Organization Journal (Feb 2023)

Latin American anaphylaxis registry

Edgardo J. Jares, MD,
Victoria Cardona, MD, PHD,
R. Maximiliano Gómez, MD, PHD,
Jonathan A. Bernstein, M.D,
Nelson A. Rosario Filho, MD,
Ivan Cherrez-Ojeda, MD, MSC,
Luis Felipe Ensina, MD PHD,
Alicia De Falco, MD,
María C. Díaz, MD,
Pierre A. Chávez Vereau, MD,
Mara M. Rocha Felix, MD, PHD,
Jorge Lavrut, MD,
Oscar I. Moreno Laflor, MD,
Patricia Latour Staffeld, MD,
Pedro Piraino, MD,
Perla Alacaraz Duarte, MD,
Juan C. Ivancevich, MD,
Fabian Dabove, MD,
Pedro Giavina-Bianchi, MD,
Iván O. Tinoco Moran, MD,
Fabiana A. Nunes Oliviera, MD,
Silvana Monsell, MD,
María V. Souza, MD,
Alfonso M. Cepeda, MD,
Pablo D. Slullitel, MD,
Blanca M. Morfin-Maciel, MD

Affiliations

Edgardo J. Jares, MD: Allergy Section, CMP S.A. LIBRA Foundation. Buenos Aires, Argentina; Corresponding author. Sucre 2496 2 D, Caba, Cp 1426, Argentina,
Victoria Cardona, MD, PHD: Allergy Section, Hospital Universitari Vall D'hebron, Barcelona, Spain
R. Maximiliano Gómez, MD, PHD: School of Health Sciences, Catholic University of Salta, Argentina
Jonathan A. Bernstein, M.D: Professor of Medicine University of Cincinnati, Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology. Cincinnati, USA
Nelson A. Rosario Filho, MD: Professor of Pediatrics, Federal University of Parana, Brazil
Ivan Cherrez-Ojeda, MD, MSC: Respiralab Research Center, Universidad Espiritu Santo, Samborondon, Ecuador
Luis Felipe Ensina, MD PHD: Faaaai Affiliate Preceptor and Research Associate Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Federal University of São Paulo, São Paulo, Brazil
Alicia De Falco, MD: Facultad De Cs Médicas Dto Posgrado Universidad Nacional De La Plata Jefe Area Alergia E Inmunología Clínica, Hospital Español De La Plata, Argentina
María C. Díaz, MD: Hospital Pedro De Elizalde, Buenos Aires, Argentina
Pierre A. Chávez Vereau, MD: Clínica Internacional, Universidad Peruana De Ciencias Aplicadas, Lima, Peru
Mara M. Rocha Felix, MD, PHD: Professor of Allergy and Immunology, Universidade Federal Do Estado Do Rio De Janeiro, Brazil
Jorge Lavrut, MD: Hospital Pedro De Elizalde, Buenos Aires, Argentina
Oscar I. Moreno Laflor, MD: Allergy and Clinical Immunology Department, Hospital Infantil De México Federico Gómez, Mexico
Patricia Latour Staffeld, MD: Universidad Nacional Pedro Henriquez Ureña, Centro Avanzado De Alergia Y Asma. Santo Domingo, Dominican Republic
Pedro Piraino, MD: Universidad Católica Ntra. Señora De La Asunción, Paraguay
Perla Alacaraz Duarte, MD: Universidad Nacional De Asunción, Paraguay
Juan C. Ivancevich, MD: Associate Professor of Immunology, Faculty of Medicine, Universidad Del Salvador, Buenos Aires, Argentina
Fabian Dabove, MD: Cemlo- Research Center Director, Lobos, Argentina
Pedro Giavina-Bianchi, MD: Associate Professor Clinical Immunology and Allergy Division, Universidade De São Paulo, São Paulo, Brazil
Iván O. Tinoco Moran, MD: Respiralab, Guayaquil, Ecuador
Fabiana A. Nunes Oliviera, MD: Division of Allergy and Clinical Immunology, Federal University of São Paulo (Unifesp), São Paulo, Brazil
Silvana Monsell, MD: Fundación Libra. Facultad De Medicina Universidad De Buenos Aires. Buenos Aires, Argentina
María V. Souza, MD: Hospital Pedro De Elizalde, Buenos Aires, Argentina
Alfonso M. Cepeda, MD: Clinical Allergy - Pediatric Allergy Fundación Hospital Universitario Metropolitano Universidad Metropolitana Barranquilla, Colombia
Pablo D. Slullitel, MD: Hospital Pedro De Elizalde Buenos Aires, Argentina
Blanca M. Morfin-Maciel, MD: Faaaai Hospital San Angel Inn Chapultepec, Ciudad De México, Mexico

Journal volume & issue: Vol. 16, no. 2
p. 100748

Abstract

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Background: Recent data about clinical features, triggers and management of anaphylaxis in Latin America is lacking. Objective: To provide updated and extended data on anaphylaxis in this region. Method: An online questionnaire was used, with 67 allergy units involved from 12 Latin-American countries and Spain. Among data recorded, demographic information, clinical features, severity, triggering agents, and treatment were received. Results: Eight hundred and seventeen anaphylactic reactions were recorded. No difference in severity, regardless of pre-existing allergy or asthma history was found. Drug induced anaphylaxis (DIA) was most frequent (40.6%), followed by food induced anaphylaxis (FIA) (32.9%) and venom induced anaphylaxis (VIA) (12%). FIA and VIA were more common in children-adolescents. Non-steroidal anti-inflammatory drugs (NSAIDs) and beta-lactam antibiotics (BLA) were the most frequent drugs involved. Milk (61.1% of FIA) and egg (15.4% of FIA) in children, and shellfish (25.5% of FIA), fresh fruits (14.2% of FIA), and fish (11.3% of FIA) in adults were the most common FIA triggers. Fire ants were the most frequent insect triggers, and they induced more severe reactions than triggers of FIA and DIA (p < 0.0001). Epinephrine was used in 43.8% of anaphylaxis episodes. After Emergency Department treatment, epinephrine was prescribed to 13% of patients. Conclusions: Drugs (NSAIDs and BLA), foods (milk and egg in children and shellfish, fruits and fish in adults) and fire ants were the most common inducers of anaphylaxis. Epinephrine was used in less than half of the episodes emphasizing the urgent need to improve dissemination and implementation of anaphylaxis guidelines.

Published in World Allergy Organization Journal

ISSN: 1939-4551 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: https://www.sciencedirect.com/journal/world-allergy-organization-journal

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