Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528

Dail E. Chapman; Babu J. N. Reddy; Bunchhin Huy; Matthew J. Bovyn; Stephen John S. Cruz; Zahraa M. Al-Shammari; Han Han; Wenqi Wang; Deanna S. Smith; Steven P. Gross

doi:10.1038/s41467-018-08110-z

Nature Communications (Jan 2019)

Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528

Dail E. Chapman,
Babu J. N. Reddy,
Bunchhin Huy,
Matthew J. Bovyn,
Stephen John S. Cruz,
Zahraa M. Al-Shammari,
Han Han,
Wenqi Wang,
Deanna S. Smith,
Steven P. Gross

Affiliations

Dail E. Chapman: Developmental and Cell Biology and Physics, University of California
Babu J. N. Reddy: Developmental and Cell Biology and Physics, University of California
Bunchhin Huy: Developmental and Cell Biology and Physics, University of California
Matthew J. Bovyn: Developmental and Cell Biology and Physics, University of California
Stephen John S. Cruz: Developmental and Cell Biology and Physics, University of California
Zahraa M. Al-Shammari: Developmental and Cell Biology and Physics, University of California
Han Han: Developmental and Cell Biology and Physics, University of California
Wenqi Wang: Developmental and Cell Biology and Physics, University of California
Deanna S. Smith: Biological Sciences, University of South Carolina
Steven P. Gross: Developmental and Cell Biology and Physics, University of California

DOI: https://doi.org/10.1038/s41467-018-08110-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Dynein plays roles in vesicular, organelle, chromosomal and nuclear transport but so far it is unclear how dynein activity in cells is regulated. Here authors study several dynein cofactors and their role in force adaptation of dynein during lipid droplet, lysosomal, and mitochondrial transport.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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