Lower HOMA-β values are detected among individuals with variant of E23K polymorphism of potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene

Abstract

Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease involving both genetic and also environmental factors. Potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) gene, an ATP-sensitive potassium channel-coding gene, contributes to insulin secretion. Objectives: This research aimed to investigate E23K polymorphism in KCNJ11 gene and insulin secretion in individuals with family history of T2DM (cases) and without family history of T2DM (controls). Method: This research was a case-control study involving 34 cases and 34 controls. E23K polymorphism of KCNJ11 was detected with PCR-RFLP. All of the obtained data were statistically analyzed with T-test, Mann–Whitney U-test, Chi-Square and One-Way ANOVA. Result: Frequency of AA genotype in individuals with family history of T2DM (41%) was higher than in individuals without family history of T2DM (6%) (p = 0.001). Frequency of A allele in individuals with family history of T2DM (68%) was higher than in individuals without family history of T2DM (38%) (p = 0.001). The risk of A allele in individuals with family history of T2DM was 3 times higher than in individuals without family history of T2DM (p = 0.001, OR 3.38, CI 95% 1.67–6.84). Homeostasis Model Assessment β (HOMA-β) values of AA genotype (85.44% ± 39.55) were lower than that of GA (212.20% ± 79.30) and GG (254.00% ± 61.98) genotypes (p = 0.000). Conclusion: The risk of having A allele in individuals with family history of T2DM is higher than that in individuals without family history of T2DM. HOMA-β values of AA genotype are lower than that of GA and GG genotypes.

Keywords

• T2DM
• E23K polymorphism of KCNJ11
• HOMA-β
• Individuals with family history of T2DM
• Individuals without family history of T2DM